ABSTRACT
Although vancomycine is used for the treatment of methicillin resistant Staphylococci, but vancomycine alone might not be effective for the treatment of methicillin resistant Staphylococci in compromised host. In the same time antimicrobial activity of cefepim on gram positive bacteria especially Staphylococci is well known. In this study the synergism effect of cefepim and vavcomycin on positive and negative coagulase Staphylococci in vitro condition was investigated. In total, 100 clinical samples of coagulase positive and negative Staphylococci were isolated from urine and blood samples from patients in Imam Khomeini Hospital during one year and identified .The modified Bauer-Kirby were used for the antibiotic susceptibility and macrodilution method for the MIC according to NCCLS procedure. The results showed that after adding vancomycin to cefepime in concentration from 0.05+ 0.5 ml micro g/ml, to 0.8+8 ml micro g/ml, growth reduction reached from 3.5% to 100%.The synergism effect of the two mentioned antibiotics on coagulase negative Staphylococci resistant to methicillin were shown that from concentration of 0.05+ 0.5 ml micro g/ml to 0.8+8 ml micro g/ml, a reduction in growth from 4.5% to 100% was observed. The results of this study showed that vancomycin and cefepime has synergic effect on Staphylococci
ABSTRACT
Background and Aim: These days with the improvements in science and technology the number of individuals who suffer from genetic disorders should be drastically less. A crucial method for preventing these disorders, in the first place, is by genetic counseling. Educating the public in regards to how they can avoid producing affected children
Materials and Methods: In this retrospective cross-sectional study, all the files of the couples attending Genetics Clinic of the Imam Khomeini Hospital Complex, during 1995 to 2004 were studied. The data were collected using a reliable questionnaire and SPSS software was applied for data analysis
Results: The most important variable in this study was the relationship between the couples. The most frequent among the consanguineous marriages was the cross first cousins [45.3%], and the least frequency belonged to non-related marriages [6.4%]. The most frequent genetic diseases belonged to children who their parents were parallel first cousins [84.8%]
Conclusion: Due to the importance of genetic counseling in relation to reducing the frequency of the genetic disorders in society, educating the general public about compulsory genetic counseling before marriage, is the cheapest and the most effective approach in limiting the number of patients with genetic abnormalities